Molecular Dissection of the Basal Clades in the Human Y Chromosome Phylogenetic Tree 英文参考文献.docVIP

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Molecular Dissection of the Basal Clades in the Human Y Chromosome Phylogenetic Tree 英文参考文献.doc

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Molecular Dissection of the Basal Clades in the Human Y Chromosome Phylogenetic Tree 英文参考文献

MolecularDissectionoftheBasalCladesintheHuman YChromosomePhylogeneticTree RosariaScozzari1,AndreaMassaia1,EugeniaD’Atanasio1,NatalieM.Myres2,3,UgoA.Perego2,4 , BeniaminoTrombetta1,FulvioCruciani1* 1DipartimentodiBiologiaeBiotecnologie‘‘CharlesDarwin’’,SapienzaUniversita`diRoma,Rome,Italy,2SorensonMolecularGenealogyFoundation,SaltLakeCity,Utah, UnitedStatesofAmerica,3AncestryDNA,Provo,Utah,UnitedStatesofAmerica,4DipartimentodiBiologiaeBiotecnologie‘‘LazzaroSpallanzani’’,Universita` diPavia, Pavia,Italy Abstract One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogenybytheanalysisof51representativeYchromosomehaplogroupsandtheuseof59mutationsfromliterature. Twenty-twonewmutationswerealsodescribedandincorporatedintherevisedphylogeny.Thisanalysismadeitpossible toidentifynewhaplogroupsandtoresolveadeeptrifurcationwithinhaplogroupB2.Ourdataprovideahighlyresolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrantoftheAfricancontinentforthehumanMSYdiversity. Citation: Scozzari R, Massaia A, D’Atanasio E, Myres NM, Perego UA, et al. (2012) Molecular Dissection of the Basal Clades in the Human YChromosome PhylogeneticTree.PLoSONE7(11):e49170.doi:10.1371/journal.pone.0049170 Editor:DavidCaramelli,UniversityofFlorence,Italy ReceivedJuly4,2012;AcceptedOctober4,2012;PublishedNovember7,2012 Copyright: ? 2012 Scozzari etal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was supported by the Italian Ministry of Education, University and Research (grant ‘‘Progetti di Ricerca di Interesse Nazionale’’, n.2009P2CNKK).Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:NMMisa