Molecular Implications of Repeated Aggression Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice 英文参考文献.docVIP

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Molecular Implications of Repeated Aggression Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice 英文参考文献.doc

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Molecular Implications of Repeated Aggression Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice 英文参考文献

MolecularImplicationsofRepeatedAggression:Th,Dat1, SncaandBdnfGeneExpressionintheVTAofVictorious MaleMice NataliaP.Bondar1.,Ul’yanaA.Boyarskikh2.,IrinaL.Kovalenko1,MaximL.Filipenko2,NataliaN. Kudryavtseva1* 1InstituteofCytologyandGeneticsSDRAS,Novosibirsk,Russia,2InstituteofChemicalBiologyandBasicMedicineSDRAS,Novosibirsk,Russia Abstract Background:Itisgenerallyrecognizedthatrecurrentaggressioncanbetheresultofvariouspsychiatricdisorders.Theaim ofourstudywastoanalyzethemRNAlevels,intheventraltegmentalarea(VTA)ofthemidbrain,ofthegenesthatmay possiblybeassociatedwithaggressionconsistentlyshownbymalemiceinspecialexperimentalsettings. Methodology/PrincipalFindings:ThegeneswereTh,Dat1,SncaandBdnf;themalemicewereagroupofanimalsthathad eachwon20dailyencountersinsuccessionandagroupofanimalsthathadthesamewinningtrackrecordfollowedbya no-fightperiodfor14days.IncreasedTh,Dat1andSncamRNAlevelswereinthefresh-from-the-fightgroupascomparedto the controls. Increased Th and Dat1 mRNA levels were in the no-fight winners as compared to the controls. Significant positivecorrelationswerefoundbetweenthelevelofaggressionandThandSncamRNAlevels. Conclusions: Repeated positive fighting experience enhances the expression of the Th, Dat1 andSnca genes, which are associatedwithbraindopaminergicsystems.TheexpressionoftheThandDat1genesstaysenhancedforalongtime. Citation:BondarNP,BoyarskikhUA,KovalenkoIL,FilipenkoML,KudryavtsevaNN(2009)MolecularImplicationsofRepeatedAggression:Th,Dat1,SncaandBdnf GeneExpressionintheVTAofVictoriousMaleMice.PLoSONE4(1):e4190.doi:10.1371/journal.pone.0004190 Editor:AlessandroBartolomucci,UniversityofParma,Italy ReceivedJuly31,2008;AcceptedDecember2,2008;PublishedJanuary14,2009 Copyright: ? 2009 Bondar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisworkwassupportedinpartbyresea