Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo 英文参考文献.docVIP

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Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo 英文参考文献.doc

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Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo 英文参考文献

MuscarinicandNicotinicModulationofThalamo- PrefrontalCortexSynapticPasticityInVivo LezioSoaresBueno-Junior1,CleitonLopes-Aguiar1,RafaelNaimeRuggiero1,RodrigoNevesRomcy- Pereira1,2*,Joa?oPereiraLeite1 1Department ofNeuroscience andBehavioralSciences,Ribeira?o Preto School of Medicine, University ofSa?o Paulo, Ribeira?o Preto, Sa?o Paulo, Brazil, 2Brain Institute, FederalUniversityofRioGrandedoNorte,Natal,RioGrandedoNorte,Brazil Abstract The mediodorsal nucleus of the thalamus (MD) is a rich source of afferents to the medial prefrontal cortex (mPFC). Dysfunctionsinthethalamo-prefrontalconnectionscanimpairnetworksimplicatedinworkingmemory,someofwhichare affected in Alzheimer disease and schizophrenia. Considering the importance of the cholinergic system to cortical functioning,ourstudyaimedtoinvestigatetheeffectsofglobalcholinergicactivationofthebrainonMD-mPFCsynaptic plasticitybymeasuringthedynamicsoflong-termpotentiation(LTP)anddepression(LTD)invivo.Therefore,ratsreceived intraventricularinjectionseitherofthemuscarinicagonistpilocarpine(PILO;40nmol/mL),thenicotinicagonistnicotine(NIC; 320nmol/mL),orvehicle.Theinjectionswereadministeredpriortoeitherthalamichigh-frequency(HFS)orlow-frequency stimulation (LFS). Test pulses were applied to MD for 30min during baseline and 240min after HFS or LFS, while field postsynaptic potentials were recorded in the mPFC. The transient oscillatory effects of PILO and NIC were monitored throughrecordingofthalamicandcorticallocalfieldpotentials.OurresultsshowthatHFSdidnotaffectmPFCresponsesin vehicle-injectedrats,butinducedadelayed-onsetLTPwithdistincteffectswhenappliedfollowingPILOorNIC.Conversely, LFSinducedastableLTDincontrolsubjects,butwasunabletoinduceLTDwhenappliedafterPILOorNIC.Takentogether, ourfindingsshowdistinctmodulatoryeffectsofeachcholinergicbrainactivationonMD-mPFCplasticityfollowingHFSand LFS. The LTP-inducing action and long-lasting suppression of cortical LTD induced by PILO and NIC might implicate differentialmodu