Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia A Voxel-Based Morphometric Study 英文参考文献.docVIP

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Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia A Voxel-Based Morphometric Study 英文参考文献.doc

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Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia A Voxel-Based Morphometric Study 英文参考文献

NeuroanatomicalCircuitryAssociatedwithExploratory EyeMovementinSchizophrenia:AVoxel-Based MorphometricStudy LinlinQiu1,2.,LinTian1,2.,ChaoPan1,2,RishengZhu1,2,QiLiu1,2,JunYan1,2,QiangZhao3,HuishuYuan3, YonghuaHan1,2,WeihuaYue1,2,HaoYan1,2*,DaiZhang1,2 * 1InstituteofMentalHealth,PekingUniversity,Beijing,People’sRepublicofChina,2KeyLaboratoryforMentalHealth,MinistryofHealth,Beijing,People’sRepublicof China,3TheDepartmentofRadiology,TheThirdHospital,PekingUniversity,Beijing,People’sRepublicofChina Abstract Schizophrenic patients present abnormalities in a variety of eye movement tasks. Exploratory eye movement (EEM) dysfunctionappearstobeparticularlyspecifictoschizophrenia.However,theunderlyingmechanismsofEEMdysfunction inschizophreniaarenotclearlyunderstood.ToassessthepotentialneuroanatomicalsubstratesofEEM,werecordedEEM performanceandconductedavoxel-basedmorphometricanalysisofgraymatterin33schizophrenicpatientsand29well matchedhealthycontrols.Inschizophrenicpatients,decreasedresponsivesearchscore(RSS)andwidespreadgraymatter density(GMD)reductionswereobserved.Moreover,theRSSwaspositivelycorrelatedwithGMDindistributedbrainregions in schizophrenic patients. Furthermore, in schizophrenic patients, some brain regions with neuroanatomical deficits overlapped with some ones associated with RSS. These brain regions constituted an occipito-tempro-frontal circuitry involvedin visualinformationprocessingandeyemovement control,includingtheleftcalcarine cortex[Brodmannarea (BA)17],theleftcuneus(BA18),theleftsuperioroccipitalcortex(BA18/19),theleftsuperiorfrontalgyrus(BA6),theleft cerebellum,therightlingualcortex(BA17/18),therightmiddleoccipitalcortex(BA19),therightinferiortemporalcortex (BA37),therightdorsolateralprefrontalcortex(BA46)andbilateralprecentralgyri(BA6)extendingtothefrontaleyefields (FEF,BA8).Toourknowledge,wefirstlyreportedempiricalevidencethatgraymatterlossintheoccipito-tempro-frontal neuroanatomicalcircuitryofvisualprocessingsystemwasassociatedwithEEMperfor