New Sequence Variants in HLA Class IIIII Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 英文参考文献.docVIP

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New Sequence Variants in HLA Class IIIII Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 英文参考文献.doc

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New Sequence Variants in HLA Class IIIII Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 英文参考文献

NewSequenceVariantsinHLAClassII/IIIRegion AssociatedwithSusceptibilitytoKneeOsteoarthritis IdentifiedbyGenome-WideAssociationStudy MasahiroNakajima1,AtsushiTakahashi2,IkuyoKou1,CristinaRodriguez-Fontenla3,JuanJ.Gomez- Reino3,4,TatsuyaFuruichi1,JinDai1,5,AkihiroSudo6,AtsumasaUchida6,NaoshiFukui7,MichiakiKubo8, NaoyukiKamatani2,TatsuhikoTsunoda9,KonstantinosN.Malizos10,11,AspasiaTsezou12 ,Antonio Gonzalez3,YusukeNakamura13,14,ShiroIkegawa1* 1LaboratoryforBoneandJointDiseases,CenterforGenomicMedicine,RIKEN,Tokyo,Japan,2LaboratoryforStatisticalAnalysis,CenterforGenomicMedicine,RIKEN, Tokyo, Japan, 3Laboratorio Investigacion 10 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 4Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain, 5The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital AffiliatedtoMedicalSchoolofNanjingUniversity,Nanjing,China,6DepartmentofOrthopaedicSurgery,MieUniversityFacultyofMedicine,Mie,Japan,7Departmentof Pathomechanisms,ClinicalResearchCenterforRheumatologyandAllergy,NationalHospitalOrganizationSagamiharaNationalHospital,Kanagawa,Japan,8Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Kanagawa, Japan, 9Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Kanagawa, Japan, 10Department of Orthopaedics University of Thessaly, Larissa, Greece, 11Institute for Biomedical Research and Technology, Larissa, Greece, 12DepartmentofBiology,UniversityofThessalyMedicalSchool,Larissa,Greece,13HumanGenomeCenter,InstituteofMedicalScience,TheUniversityofTokyo,Tokyo, Japan,14CenterforGenomicMedicine,RIKEN,Kanagawa,Japan Abstract Osteoarthritis(OA)isacommondiseasethathasadefinitegeneticcomponent.OnlyafewOAsusceptibilitygenesthat have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ,4,800 Japanese s