New World Hantaviruses Activate IFNλ Production in Type I IFN-Deficient Vero E6 Cells 英文参考文献.docVIP

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New World Hantaviruses Activate IFNλ Production in Type I IFN-Deficient Vero E6 Cells 英文参考文献.doc

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New World Hantaviruses Activate IFNλ Production in Type I IFN-Deficient Vero E6 Cells 英文参考文献

NewWorldHantavirusesActivateIFNlProductionin TypeIIFN-DeficientVeroE6Cells JosephPrescott1,PamelaHall2,MarianaAcuna-Retamar3,ChunyanYe3,MarcG.Wathelet3,6 ,Hideki Ebihara1,HeinzFeldmann1*,BrianHjelle3,4,5 1LaboratoryofVirology,DivisionofIntramuralResearch,NationalInstituteofAllergyandInfectiousDisease,NationalInstitutesofHealth,RockyMountainLaboratories, Hamilton,Montana,UnitedStatesofAmerica, 2ResearchService(151),NewMexicoVeteransAffairsHealthCareSystem,Albuquerque, NewMexico,UnitedStatesof America, 3Department of Pathology, Center for Infectious Diseases and Immunity, School of Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America, 4Department of Biology, Center for Infectious Diseases and Immunity, School of Medicine, University of New Mexico, Albuquerque, New Mexico, United StatesofAmerica,5DepartmentofMolecularGenetics andMicrobiology, CenterforInfectiousDiseases andImmunity,School ofMedicine,UniversityofNew Mexico,Albuquerque,NewMexico,UnitedStatesofAmerica,6InfectiousDiseaseProgram,LovelaceRespiratoryResearchInstitute,Albuquerque,NewMexico,United StatesofAmerica Abstract Background: Hantaviruses indigenous to the New World are the etiologic agents of hantavirus cardiopulmonary syndrome (HCPS). These viruses induce a strong interferon-stimulated gene (ISG) response in human endothelial cells. Africangreenmonkey-derivedVeroE6cellsareusedtopropagatehantavirusesaswellasmanyotherviruses.Theutility of the Vero E6 cell line for virus production is thought to owe to their lack of genes encoding type I interferons (IFN), rendering them unable to mount an efficient innate immune response to virus infection. Interferon l, a more recently characterizedtypeIIIIFN,istranscriptionallycontrolledmuchlikethetypeIIFNs,andactivatestheinnateimmunesystem inasimilar manner. Methodology/PrincipalFindings:WeshowthatVeroE6cellsrespondtohantavirusinfectionbysecretingabundantIFNl. ThreeNewWorldhantavirusesweresimilarlyabletoinduceIFNlexpre