Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation 英文参考文献.docVIP
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Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation 英文参考文献
NovelInhibitorsofStaphylococcusaureusVirulence
GeneExpressionandBiofilmFormation
YibaoMa1,YuanxiXu1,BryanD.Yestrepsky2,RoderickJ.Sorenson2,MengChen3,ScottD.Larsen2*,
HongminSun1*
1Department of Internal Medicine, University of Missouri, Columbia, Missouri, United States of America, 2Vahlteich Medicinal Chemistry Core, College of Pharmacy,
UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica,3Nanova,Inc.,Columbia,Missouri,UnitedStatesofAmerica
Abstract
Staphylococcus aureus is a major human pathogen and one of the more prominent pathogens causing biofilm related
infections in clinic. Antibiotic resistance in S. aureus such as methicillin resistance is approaching an epidemic level.
Antibiotic resistance is widespread among major human pathogens and poses a serious problem for public health.
Conventional antibiotics are either bacteriostatic or bacteriocidal, leading to strong selection for antibiotic resistant
pathogens.Analternativeapproachofinhibitingpathogenvirulencewithoutinhibitingbacterialgrowthmayminimizethe
selectionpressureforresistance.Inpreviousstudies,weidentifiedachemicalseriesoflowmolecularweightcompounds
capable of inhibiting group A streptococcus virulence following this alternative anti-microbial approach. In the current
study, we demonstrated that two analogs of this class of novel anti-virulence compounds also inhibited virulence gene
expression of S. aureus and exhibited an inhibitory effect on S. aureus biofilm formation. This class of anti-virulence
compoundscouldbeastartingpointfordevelopmentofnovelanti-microbialagentsagainstS.aureus.
Citation: Ma Y, Xu Y, Yestrepsky BD, Sorenson RJ, Chen M, et al. (2012) Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm
Formation.PLoSONE7(10):e47255.doi:10.1371/journal.pone.0047255
Editor:StefanBereswill,Charite′-University MedicineBerlin,Germany
ReceivedJuly2,2012;AcceptedSeptember10,2012;PublishedOctober15,2012
Copyright:?2012Maetal.Thisisanopen-accessarticledistribut
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