Novel, Meso-Substituted Cationic Porphyrin Molecule for Photo-Mediated Larval Control of the Dengue Vector Aedes aegypti 英文参考文献.docVIP
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Novel, Meso-Substituted Cationic Porphyrin Molecule for Photo-Mediated Larval Control of the Dengue Vector Aedes aegypti 英文参考文献
Novel,Meso-SubstitutedCationicPorphyrinMoleculefor
Photo-MediatedLarvalControloftheDengueVector
Aedesaegypti
LeonardoLucantoni1*,MichelaMagaraggia2,GiulioLupidi1,RobertKossiviOuedraogo4 ,Olimpia
Coppellotti2,FulvioEsposito3,ClaraFabris2,GiulioJori2,AnnetteHabluetzel1
1SchoolofPharmacy,UniversityofCamerino,Camerino,Italy,2DepartmentofBiology,UniversityofPadova,Padova,Italy,3SchoolofBioscienceandBiotechnology,
UniversityofCamerino,Camerino,Italy,4InstitutdeRechercheenSciencesdelaSante′ (IRSS),Bobo-Dioulasso,BurkinaFaso
Abstract
Background:Controlofthemosquitovectorpopulationisthemosteffectivestrategycurrentlyavailablefortheprevention
ofdenguefeverandthecontainmentofoutbreaks.Photo-activatedoxidantsmayrepresentpromisingtoolsfordeveloping
effective, safe and ecofriendly novel larvicides. The purpose of this study was to evaluate the potential of the synthetic
meso-substituted porphyrin meso-tri(N-methylpyridyl), meso-mono(N-tetradecylpyridyl)porphine (C14) as a photoactiva-
tablelarvicideagainstthedenguevectorAedes(Stegomyia)aegypti.
Methodology: The photophysical and photochemical properties of the C14 molecule were assessed spectrophotomet-
rically. Photomediated larvicidal efficacy, route of intake and site of action were determined on Ae. aegypti larvae by
laboratory bioassays and fluorescence microscopy. Using powdered food pellet for laboratory rodents (a common larval
foodusedinthelaboratory)asacarrierforC14,loading-releasedynamics,larvicidalefficacyandresidualactivityoftheC14-
carriercomplexwereinvestigated.
MainFindings:TheC14moleculewasfoundtoexertapotentphotosensitizingactivityonAe.aegyptilarvae.Atirradiation
intervalsof12hand1h,atalightintensityof4.0mW/cm2,whichis50–100timeslowerthanthatofnaturalsunlight,LC
50
valuesof0.1mM(0.15mg/l)and0.5mM(0.77mg/l)wereobtained,respectively.Themoleculewasactiveafteringestionby
thelarvaeandcausedirreversible,lethaldamagetothemidgutandcaecalepithelia.TheamphiphilicnatureofC14allowed
aformulatetobeproducedthatnotonly
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