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NT-ProBNP Levels in Saliva and Its Clinical Relevance to Heart Failure 英文参考文献
NT-ProBNPLevelsinSalivaandItsClinicalRelevanceto
HeartFailure
JaredYongYangFoo1,YunxiaWan1,KaramKostner2,3,AliciaArivalagan2,3,JohnAtherton2,4
JustinCooper-White1,5,GoceDimeski2,6,ChamindiePunyadeera1,5
,
*
1The Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia, 2School of Medicine, University of
Queensland, Brisbane, Queensland, Australia, 3Department of Cardiology, Mater Adult Hospital, Brisbane, Queensland, Australia, 4Department of Cardiology, Royal
BrisbaneandWomen’sHospital,Brisbane,Queensland,Australia,5SchoolofChemicalEngineering,UniversityofQueensland,Brisbane,Queensland,Australia,6Chemical
Pathology,PrincessAlexandraHospital,Brisbane,Queensland,Australia
Abstract
Background: Current blood based diagnostic assays to detect heart failure (HF) have large intra-individual and inter-
individualvariationswhichhavemadeitdifficulttodeterminewhetherthechangesintheanalytelevelsreflectanactual
changeindiseaseactivity.Humansalivamirrorsthebody’shealthandwellbeingand,20%ofproteinsthatarepresentin
bloodarealsofoundinsaliva.Salivahasnumerousadvantagesoverbloodasadiagnosticfluidwhichallowsforanon-
invasive,simple,andsafesamplecollection.TheaimofourstudywastodevelopanimmunoassaytodetectNT-proBNPin
salivaandtodetermineifthereisacorrelationwithbloodlevels.
Methods:Salivasampleswerecollectedfromhealthyvolunteers(n=40)whohadnounderlyingheartconditionsandHF
patients(n=45)atrest.Sampleswerestoredat280uCuntilanalysis.AcustomisedhomogeneoussandwichAlphaLISA(R)
immunoassaywasusedtoquantifyNT-proBNPlevelsinsaliva.
Results:OurNT-proBNPimmunoassaywasvalidatedagainstacommercialRocheassayonplasmasamplescollectedfrom
6+1910.8).ThemediansalivaryNT-proBNPlevelsin
HFpatients(n=37)andthecorrelationwasr2=0.78(p,0.01,y=1.705
the healthy and HF participants were ,16pg/mL and 76.8pg/mL, respectively. The salivary NT-proBNP immunoassay
showed a clinical sensitivity of 82.2% and specificity of 100%, positive predictive value of
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