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Nuclear Actin and Lamins in Viral Infections 英文参考文献
Viruses 2012, 4, 325-347; doi:10.3390/v4030325
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
Nuclear Actin and Lamins in Viral Infections
Jakub Cibulka, Martin Fraiberk and Jitka Forstova *
Charles University in Prague, Faculty of Science, Department of Genetics and Microbiology,
Vinicna 5, 12844, Prague 2, Czech Republic; E-Mails: jakubcib@ (J.C.);
martin.fraiberk@natur.cuni.cz (M.F.)
* Author to whom correspondence should be addressed; E-Mail: jitkaf@natur.cuni.cz;
Tel.: +420-221951730; Fax: +420-221951724.
Received: 24 January 2012; in revised form: 20 February 2012 / Accepted: 21 February 2012 /
Published: 28 February 2012
Abstract: Lamins are the best characterized cytoskeletal components of the cell nucleus
that help to maintain the nuclear shape and participate in diverse nuclear processes
including replication or transcription. Nuclear actin is now widely accepted to be another
cytoskeletal protein present in the nucleus that fulfills important functions in the gene
expression. Some viruses replicating in the nucleus evolved the ability to interact with and
probably utilize nuclear actin for their replication, e.g., for the assembly and transport of
capsids or mRNA export. On the other hand, lamins play a role in the propagation of other
viruses since nuclear lamina may represent a barrier for virions entering or escaping the
nucleus. This review will summarize the current knowledge about the roles of nuclear actin
and lamins in viral infections.
Keywords: viruses; nuclear actin; nuclear lamina; lamin; cytoskeleton; nucleus
1. Introduction
Viruses are intracellular pathogens known to employ various host-cell mechanisms to facilitate their
replication. The cell cytoskeleton is not an exception. To date, many interactions between viruses and
cytoskeleton have been described including virus entry, transport of viral particles in the cytoplasm,
and release of progeny virions [1].
Viru
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