Polymorphisms in the CYP2E1 and GSTM1 Genes as Possible Protection Factors for Leprosy Patients 英文参考文献.docVIP
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Polymorphisms in the CYP2E1 and GSTM1 Genes as Possible Protection Factors for Leprosy Patients 英文参考文献
PolymorphismsintheCYP2E1andGSTM1Genesas
PossibleProtectionFactorsforLeprosyPatients
PabloPinto1,ClaudioGuedesSalgado2,NeySantos1,DayseO.Alencar1,SidneySantos1,MaraH.Hutz3,
Andrea? Ribeiro-dos-Santos1*
1Laborato′riodeGene′ticaHumanaeMe′dica,Instituto deCie?ncias Biolo′gicas, UniversidadeFederaldoPara′, Bele′m,Para′, Brasil,2Laborato′riodeDermatoimunologia,
Instituto de Cie?ncias Biolo′gicas, Universidade Federal do Para′, Bele′m, Para′, Brasil, 3Instituto de Biocie?ncias, Departamento de Gene′tica, Universidade Federal do Rio
GrandedoSul,RioGrandedoSol,Brasil
Abstract
Background:TheCYP2E1andGSTM1genesencodemetabolicenzymesthathavekeyfunctionsindrugmodificationand
elimination.
Methodology/PrincipalFindings:WeinvestigatedthepossibleeffectsofCYP2E1andGSTM1polymorphismsin71leprosy
patients and in 110 individuals from the general population. The GSTM1*0 null allele and INDEL CYP2E1*1D mutant
genotypeswereanalyzedbyconventionalPCR,whileCYP2E1SNPs(1053C.T,1293G.Cand7632T.A)weredetermined
by RT-PCR. In leprosy patients, the GSTM1*0 and CYP2E1*5 alleles and the combined alleles GSTM1*0/CYP2E1*6 and
GSTM1*0/CYP2E1*5weresignificantlyrelatedtoabaciloscopicindex(BI)(BI,3),whiletheCYP2E1*6allelewasrelatedtoa
betterclinicalevolutionintheleprosyspectrum.
Conclusions/Significance: Therefore, GSTM1*0, CYP2E1*5 and CYP2E1*6 may be possible protection factors for leprosy
patients.
Citation:PintoP,SalgadoCG,SantosN,AlencarDO,SantosS,etal.(2012)PolymorphismsintheCYP2E1andGSTM1GenesasPossibleProtectionFactorsfor
LeprosyPatients.PLoSONE7(10):e47498.doi:10.1371/journal.pone.0047498
Editor:TanyaParish,QueenMaryUniversityofLondon,UnitedKingdom
ReceivedApril3,2012;AcceptedSeptember17,2012;PublishedOctober15,2012
Copyright: ? 2012 Pinto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding: This study w
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