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AAPS PharmSciTech 2007; 8 (1) Article 3 (). Comparison of a Laboratory and a Production Coating Spray Gun With Respect to Scale-up Submitted: January 5, 2006; Accepted: July 13, 2006; Published: January 19, 2007 Ronny Mueller1 and Peter Kleinebudde1 1Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr.1, 40225 Duesseldorf, Germany ABSTRACT The influence of formulation factors such as density, sur- face tension, viscosity, and process factors such as spray rate, A laboratory spray gun and a production spray gun were atomization air pressure, distance from spray gun, spray investigated in a scale-up study. Two Schlick spray guns, shape, spray gun design, and liquid nozzle diameter on drop- which are equipped with a new antibearding cap, were used let size, droplet velocity, and spray density was described in this study. The influence of the atomization air pressure, 2 by Aulton and Twitchell. The polymer dispersion viscosity spray gun-to tablet bed distance, polymer solution viscos- is one of the most important formulation variables. The ef- ity, and spray rate were analyzed in a statistical design of fects of different parameters (spray rate, gun-to-tablet bed experiments. The 2 spray guns were compared with respect