Predicting treatment outcome in classical Hodgkin lymphoma genomic advances 英文参考文献.docVIP

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Predicting treatment outcome in classical Hodgkin lymphoma genomic advances 英文参考文献.doc

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Predicting treatment outcome in classical Hodgkin lymphoma genomic advances 英文参考文献

Derenzini E and Younes A Genome Medicine 2011,3:26 /content/3/4/26 RE VIE W Predicting treatment outcome in classical Hodgkin lymphoma: genomic advances Enrico Derenzini and Anas Younes* 1 2 approximately 11% of all lymphomas in western countries and has a bimodal age distribution, with a ?rst peak in young adults and a second peak around 59 years of age [1,2]. HL is currently classi?ed as two distinct disease entities: nodular lymphocyte-predominant HL (NLPHL) and classical Hodgkin lymphoma (cHL) [2,3]. In fact, Abstract Classical Hodgkin lymphoma is considered a highly curable disease; however, 20% of patients cannot be cured with standard rst-line chemotherapy and have a dismal outcome. Current clinical parameters do not allow accurate risk stratication, and personalized therapies are lacking. In fact, Hodgkin lymphoma (HL) is often over- or undertreated because of this lack of accurate risk stratication. In recent years, the early detection of chemoresistance by -uorodeoxyglucose positron emission tomography has become the most important prognostic tool in the management of HL. However, to date, no prognostic scores or molecular markers are available for the early identication of patients at very high risk of failure of induction therapy. In the last decade, many important advances have been made in understanding the biology of HL. In particular, the development of new molecular proling technologies, such as SNP arrays, comparative genomic hybridization, and gene-expression proling, have allowed the identication of new prognostic factors that may be useful for risk stratication and predicting response to chemotherapy. In this review, we focus on the prognostic tools and biomarkers that are available for newly diagnosed HL, and we highlight recent advances in the genomic characterization of classical HL and potential targets for therapy. these histologic subtypes have