Pretreatment Lifestyle Behaviors as Survival Predictors for Patients with Nasopharyngeal Carcinoma 英文参考文献.docVIP

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Pretreatment Lifestyle Behaviors as Survival Predictors for Patients with Nasopharyngeal Carcinoma 英文参考文献.doc

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Pretreatment Lifestyle Behaviors as Survival Predictors for Patients with Nasopharyngeal Carcinoma 英文参考文献

PretreatmentLifestyleBehaviorsasSurvivalPredictors forPatientswithNasopharyngealCarcinoma Guo-PingShen1,2,Feng-HuaXu1,FenHe1,3,Hong-LianRuan1,CuiCui1,Li-ZhenChen1,Yi-XinZeng1, Wei-HuaJia1* 1StateKeyLaboratoryofOncologyinSouthChina,CancerCenter,SunYat-senUniversity,Guangzhou,China,2DepartmentofRadiationOncology,TheFirstAffiliated Hospital,SunYat-senUniversity,Guangzhou,China,3DepartmentofRadiationOncology,TheFirstAffiliatedHospital,GuangzhouMedicalUniversity,Guangzhou,China Abstract Background:Lifestylebehaviorshavebeenwidelyreportedtoinfluencethesurvivalofpatientswithheadandneckcancer. However, the relationship between pretreatment lifestyle behaviors and survival among patients with nasopharyngeal carcinoma(NPC)isunclear. Methods:Aprospectivecohortstudywasdesignedtodeterminetherelationshipbetweenlifestylebehaviorsandsurvival in1,533NPCpatientsrecruitedfromOctober2005toOctober2007.Pretreatmentlifestylebehaviors(suchasbody-mass index [BMI], smoking, alcohol, diet) of the patients were investigated. Univariate and multivariate proportional-hazards modelswereusedtoassesstheimpactoflifestylebehaviorsonpatientsurvival. Results:Smokingwasapredictorofsurvival;bothcurrentsmokers(hazardratio[HR]=1.88;95%CI,1.33to2.65)andheavy smokers ($25 Pack-years; HR=1.84; 95% CI, 1.30 to 2.60) showed associations with poor survival. Higher BMI was significantlyassociatedwithalowerriskofdeath(Ptrend=0.002).Comparedwithunder/normal-weightpatients(BMIless than 22.99kg/m2), the multivariate HR for survival was 0.66 (95% CI, 0.48 to 0.90) and 0.47 (95% CI, 0.23 to 0.97) for overweightandobesepatients,respectively.Noalcoholintakeandhighfruitintakewereassociatedwithfavorablesurvival intheunivariateanalysisbutlostsignificanceinthemultivariatemodel. Conclusion: Our findings indicate that pretreatment lifestyle behaviors, especially smoking status and BMI, as easily availabledata,provideprognosticvalueforsurvivalinNPCpatients. Citation: Shen G-P, Xu F-H, He F, Ruan H-L, Cui C, et al. (2012) Pret