Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines 英文参考文献.docVIP

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Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines 英文参考文献.doc

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Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines 英文参考文献

ProbableCongenitalTransmissionof ReticuloendotheliosisVirusCausedbyVaccinationwith ContaminatedVaccines KaiWei.,ZhenhongSun.,ShufenZhu,WenlongGuo,PengchengSheng,ZunminWang, ChangliangZhao,QingyouZhao,RuiliangZhu* KeyLaboratoryofBiologicalProduct,CollegeofAnimalScienceandTechnology,ShandongAgriculturalUniversity,Taian,Shandong,People’sRepublicofChina Abstract Contaminatedvaccineisoneunexpectedandpotentialoriginofvirusinfection.Inordertoinvestigatethemostlikelycause of diseasein abroiler breeder company ofShandong Province,all 17batches of live-virus vaccinesused intheaffected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreakofdiseasewasmostprobablyduetothevaccinationofREV-contaminatedMD-CVI988/RispensvaccinesandND- LaSota+IB-H120vaccines.Furthermore,theREVwasprobablytransmittedtothecommercialchickensthroughcongenital transmission. Citation: Wei K, Sun Z, Zhu S, Guo W, Sheng P, et al. (2012) Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with ContaminatedVaccines.PLoSONE7(8):e43422.doi:10.1371/journal.pone.0043422 Editor:RogerLeGrand,Commissariatal’EnergieAtomique(cea),France ReceivedApril30,2012;AcceptedJuly20,2012;PublishedAugust17,2012 Copyright:?2012Weietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNationalNaturalScienceFoundationofChina30740077),SpecialFundResearchofPublicWelfareIndustriesof MinistryofAgriculture(200803019),andScienceandTechnologyDevelopmentPlanofShandongProvince(2012GNC11020).Thefundershadnoroleinstudy design,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:zhurl@ .Theseauthorscontributedequallytothiswork. Introduction demonstrat