Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies 英文参考文献.docVIP

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Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies 英文参考文献.doc

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Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies 英文参考文献

Open Access Me d 2009LaajalaetVolul.metho10, Issue 7, Article R77 Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies Essi Laajala*, Tero Aittokallio*?, Riitta Lahesmaa* and Laura L Elo*? Addresses: *Turku Centre for Biotechnology, University of Turku and ?bo Akademi University, Turku, FI-20521, Finland. ?Department of Mathematics, University of Turku, Turku, FI-20014, Finland. Correspondence: Laura L Elo. Email: laliel@utu.fi Published: 16 July 2009 Received: 16 March 2009 Revised: 5 June 2009 Accepted: 16 July 2009 Genome Biology 2009, 10:R77 (doi:10.1186/gb-2009-10-7-r77) The electronic version of this article is the complete one and can be found online at /2009/10/7/R77 ? 2009 Laajala et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DetectingppA novedifferentiall statisticalsplicingprocedure is presented that uses probe-level information on Affymetrix exon arrays to detect differential splicing./ Abstract The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the probe-level information on Affymetrix exon arrays when detecting differential splicing between sample groups. In comparison to existing ranking methods, the procedure shows superior reproducibility and accuracy in distinguishing true biological findings from background noise in high agreement with experimental validations. Background eases [5,6]. In particular, a number of genetic point muta- tions associated with human hereditary diseases have been linked to disrupted splicing [6]. Hence, a comprehensive understanding of