Prothrombin complex concentrate (Beriplex PN) in severe bleeding experience in a large tertiary hospital 英文参考文献.docVIP

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Prothrombin complex concentrate (Beriplex PN) in severe bleeding experience in a large tertiary hospital 英文参考文献.doc

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Prothrombin complex concentrate (Beriplex PN) in severe bleeding experience in a large tertiary hospital 英文参考文献

Available online /content/12/4/R105 Research Open Access Vol 12 No 4 Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital David Bruce and Tim JC Nokes Department of Haematology, Derriford Hospital, Brest Road, Plymouth, Devon PL6 8DH, UK Corresponding author: Tim JC Nokes, tim.nokes@phnt.swest.nhs.uk Received: 7 Apr 2008 Revisions requested: 9 May 2008 Revisions received: 1 Jul 2008 Accepted: 15 Aug 2008 Published: 15 Aug 2008 Critical Care 2008, 12:R105 (doi:10.1186/cc6987) This article is online at: /content/12/4/R105 ? 2008 Bruce and Nokes; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Major blood loss can often be life-threatening and is most commonly encountered in the settings of surgery and trauma. Patients receiving anticoagulant therapy are also at increased risk of bleeding. We investigated the use of a prothrombin complex concentrate (PCC; Beriplex P/N, CSL Behring, Marburg, Germany) to treat severe bleeding in a variety of settings: cardiac surgery, warfarin therapy and other surgery. 1). Therefore, 24 patients were included in the analysis: coronary artery bypass graft (n = 5), mitral/aortic valve replacement (n = 2), other surgery (n = 9) and warfarin reversal (n = 8). Most patients (83.3%) received no more than 1500 IU of Beriplex P/N 500. Considerable reduction in administration of other blood products was seen during the 24 hours after PCC administration. Partial or complete haemostasis was achieved in 14 out of 18 cases (77.8%). In total, 12 out of 24 patients (50%) died during the study; two-thirds of the deaths were considered unrelated to bleeding. No thrombotic complications or ad