Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses Health Study II 英文参考文献.docVIP

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Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses Health Study II 英文参考文献.doc

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Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses Health Study II 英文参考文献

BMC Psychiatry BioMedCentral Study protocol Open Access Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses Health Study II Karestan C Koenen*1,3, Immaculata De Vivo2,3, Janet Rich-Edwards2,3, Jordan W Smoller4, Rosalind J Wright1,3 and Shaun M Purcell4,5 Address: 1Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA, 2Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, 3Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA, 4Department of Psychiatry, Psychiatric and Neurodevelopment Genetics Unit, Center for Genetic Research Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA and 5The Broad Institute, Cambridge, MA 02141, USA Email: Karestan C Koenen* - kkoenen@; Immaculata De Vivo - devivo@; Janet Rich- Edwards - jr33@; Jordan W Smoller - jordan_smoller@; Rosalind J Wright - rosalind.wright@; Shaun M Purcell - shaun@ * Corresponding author Published: 29 May 2009 Received: 17 April 2009 Accepted: 29 May 2009 BMC Psychiatry 2009, 9:29 doi:10.1186/1471-244X-9-29 This article is available from: /1471-244X/9/29 ? 2009 Koenen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: One in nine American women will meet criteria for the diagnosis of posttraumatic stress disorder (PTSD) in their lifetime. Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder. Methods and design: We are using the unique resource of the Nurses Health Study II,