Randomized controlled trial of Hepatitis B virus vaccine in HIV-1-infected patients comparing two different doses 英文参考文献.docVIP
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Randomized controlled trial of Hepatitis B virus vaccine in HIV-1-infected patients comparing two different doses 英文参考文献
AIDS Research and Therapy
BioMedCentral
Research
Open Access
Randomized controlled trial of Hepatitis B virus vaccine in
HIV-1-infected patients comparing two different doses
Patricia Cornejo-Juárez*?1, Patricia Volkow-Fernández?1, Kenia Escobedo-
López2, Diana Vilar-Compte1, Guillermo Ruiz-Palacios2 and
Luis Enrique Soto-Ramírez?2
Address: 1Infectious Diseases, Instituto Nacional de Cancerología, Mexico City, México. Av. San Fernando No. 22, Col. Sección XVI, Tlalpan, 14000
México, D.F, Mexico and 2Infectious Diseases, Instituto Nacional de Ciencias Médicas y de la Nutrición. Salvador Zubirán, Mexico City, Mexico
Email: Patricia Cornejo-Juárez* - patcornejo@; Patricia Volkow-Fernández - volkow@.mx; Kenia Escobedo-
López - kemesk@; Diana Vilar-Compte - diana-vilar@.mx; Guillermo Ruiz-Palacios - gmrps@servidor.unam.mx;
Luis Enrique Soto-Ramírez - lsoto@quetzal.innsz.mx
* Corresponding author ?Equal contributors
Published: 06 April 2006
Received: 18 October 2005
Accepted: 06 April 2006
AIDS Research and Therapy2006, 3:9
doi:10.1186/1742-6405-3-9
This article is available from: /content/3/1/9
? 2006Cornejo-Juárez et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Co-infection with hepatitis B virus (HBV) and human immunodeficiency virus (HIV)
is not infrequent as both share same route of exposure. The risk of developing chronic hepatitis B
virus is 6%, in general population but can reach 10–20% in HBV/HIV co-infected patients. When
compared to general population, the response rate to HBV vaccine in HIV-infected patients is
diminished, so previous studies have tried to improve this response using variety of schedules,
doses and co-administration of immunomodulators. The purpose of th
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