Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study 英文参考文献.docVIP

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Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study 英文参考文献.doc

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Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study 英文参考文献

ReducedRiskofPlasmodiumvivaxMalariainPapuaNew GuineanChildrenwithSoutheastAsianOvalocytosisin TwoCohortsandaCase-ControlStudy AnnaRosanas-Urgell1.,EnmooreLin1.,LaurensManning2,PatriciaRarau1,MosesLaman1, NicolasSenn1,3,BrianT.Grimberg4,LivingstoneTavul1,DanielleI.Stanisic1,5,LeanneJ.Robinson1,5 JohnJ.Aponte6,ElijahDabod1,JohnC.Reeder7,PeterSiba1,PeterA.Zimmerman4,TimothyM.E.Davis2, ChristopherL.King4,8,PascalMichon1,9,IvoMueller1,5,6 , * 1PNGInstituteofMedicalResearch,Madang,PapuaNewGuinea,2DepartmentofMedicinePharmacology,UniversityofWesternAustralia,Perth,Australia,3Swiss TropicalPublicHealthInstitute,Basel,Switzerland,4CenterofGlobalHealthDiseases(CGHD),CaseWesternReserveUniversity,Cleveland,Ohio,UnitedStatesof America,5InfectionImmunityDivision,Walter+ElizaHallInstitute,Parkville,Victoria,Australia,6BarcelonaCentreforInternationalHealthResearch(CRESIB,Hospital Cl?′nic-Universitat de Barcelona), Barcelona, Spain, 7The Burnet Institute, Melbourne, Australia, 8Veterans Affairs Medical Center, Cleveland, Ohio, United States of America,9FacultyofHealthSciences,DivineWordUniversity,Madang,PapuaNewGuinea Abstract Background:Theerythrocytepolymorphism,SoutheastAsianovalocytosis(SAO)(whichresultsfroma27-basepairdeletion intheerythrocyteband3gene,SLC4A1D27)protectsagainstcerebralmalariacausedbyPlasmodiumfalciparum;however,it isunknownwhetherthispolymorphismalsoprotectsagainstP.vivaxinfectionanddisease. MethodsandFindings:TheassociationbetweenSAOandP.vivaxinfectionwasexaminedthroughgenotypingof1,975 childrenenrolledinthreeindependentepidemiologicalstudiesconductedintheMadangareaofPapuaNewGuinea.SAO wasassociatedwithastatisticallysignificant46%reductionintheincidenceofclinicalP.vivaxepisodes(adjustedincidence rateratio[IRR]=0.54,95%CI0.40–0.72,p,0.0001)inacohortofinfantsaged3–21monthsandasignificant52%reduction inP.vivax(blood-stage)reinfectiondiagnosedbyPCR(95%CI22–71,p=0.003)and55%bylightmicroscopy(95%CI13–77, p=0.014),respectively,inacohortofchildrenaged5–14years.SAOwasa