Regulation of Slow and Fast Muscle Myofibrillogenesis by Wntβ-Catenin and Myostatin Signaling 英文参考文献.docVIP

下载本文档

5
0
约5.02万字
约 12页
2017-05-13 发布于上海
举报
版权申诉

Regulation of Slow and Fast Muscle Myofibrillogenesis by Wntβ-Catenin and Myostatin Signaling 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Regulation of Slow and Fast Muscle Myofibrillogenesis by Wntβ-Catenin and Myostatin Signaling 英文参考文献

RegulationofSlowandFastMuscleMyofibrillogenesis byWnt/b-CateninandMyostatinSignaling Jin-MingTee,CarinavanRooijen,RickBoonen,DanicaZivkovic* HubrechtInstituteforDevelopmentalBiologyandStemCellResearchandUniversityMedicalCenter,Utrecht,TheNetherlands Abstract Deviationfrompropermuscledevelopmentorhomeostasisresultsinvariousmyopathicconditions.Employinggeneticas wellaschemicalintervention,weprovideevidencethatatightregulationofWnt/b-cateninsignalingisessentialformuscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/b-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effectsofWnt/b-cateninsignalingonfastmusclehypertrophywererescuedbymisexpressionofMyostatinorp21CIP/WAF , establishinganinvivoregulationofmyofibrillogenesisbyWnt/b-cateninsignalingandMyostatin.Epistaticanalysessuggest a possible genetic interaction between Wnt/b-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis. Citation: Tee J-M, van Rooijen C, Boonen R, Zivkovic D (2009) Regulation of Slow and Fast Muscle Myofibrillogenesis by Wnt/b-Catenin and Myostatin Signaling.PLoSONE4(6):e5880.doi:10.1371/journal.pone.0005880 Editor:GianniParise,McMasterUniversity,Canada ReceivedDecember19,2008;AcceptedMay19,2009;PublishedJune11,2009 Copyright:?2009Teeetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:WorkwasfundedbyALWGrantThefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparation ofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:d.zivkovic@hubrecht.eu Introduction [19], the precise molecular mechanism underlying specification andmaintenanceofsecondaryfasttwitchmusclefibersaswellas theHedgehogindepen