Cord Blood CD4+ T Cells Respond to Self Heat Shock Protein 60 (HSP60) 英文参考文献.docVIP

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Cord Blood CD4+ T Cells Respond to Self Heat Shock Protein 60 (HSP60) 英文参考文献.doc

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CordBloodCD4TCellsRespondtoSelfHeatShockProtein60(HSP60)英文参考文献

CordBloodCD4+TCellsRespondtoSelfHeatShock Protein60(HSP60) JoostA.Aalberse1*,BerberKapitein1,SytzedeRoock1,MarkR.Klein1,WilcodeJager1,Ruurdvander Zee2,MaartenO.Hoekstra3,FemkevanWijk1,BerentJ.Prakken1 1Department of Pediatric Immunology, Wilhelmina Children’s Hospital, Utrecht, The Netherlands, 2Department of Infectious Diseases and Immunology, Faculty of VeterinaryMedicine,UtrechtUniversity,Utrecht,TheNetherlands,3DepartmentofPediatrics,RadboudUniversityNijmegenMedicalCentre,Nijmegen,TheNetherlands Abstract Background: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contributetoperipheraltolerance.ItisnotknownwhetherHSP60-specificTcellsarepresentatbirthandthusmayplaya role in neonatal tolerance. We studied whether self-HSP60 reactive T cells are present in cord blood, and if so, what phenotypethesecellshave. Methodology/Principal Findings: Cord blood mononuclear cells (CBMC) of healthy, full term neonates (n=21), were culturedwithHSP60andTetanusToxoid(TT)tostudyantigenspecificproliferation,cytokinesecretionandup-regulationof surface markers. The functional capacity of HSP60-induced T cells was determined with in vitro suppression assays. + StimulationofCBMCwithHSP60ledtoCD4 Tcellproliferationandtheproductionofvariouscytokines,mostnotablyIL-10, Interferon-gamma,andIL-6.HSP60-inducedTcellsexpressedFOXP3andsuppressedeffectorTcellresponsesinvitro. Conclusion:Self-reactiveHSP60specificTcellsarealreadypresentatbirth.Uponstimulationwithself-HSP60thesecells proliferate,producecytokinesandexpressFOXP3.Thesecellsfunctionassuppressorcellsinvitroandthustheymaybe involvedintheregulationofneonatalimmuneresponses. Citation:AalberseJA,KapiteinB,deRoockS,KleinMR,deJagerW,etal.(2011)CordBloodCD4+TCellsRespondtoSelfHeatShockProtein60(HSP60).PLoS ONE6(9):e24119.doi:10.1371/journal.pone.0024119 Editor:DeryaUn