Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring 英文参考文献.docVIP
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Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring 英文参考文献
Rizzardietal.DiagnosticPathology2012,7:42
/content/7/1/42
RESEARCH
OpenAccess
Quantitativecomparisonofimmunohistochemical
stainingmeasuredbydigitalimageanalysis
versuspathologistvisualscoring
AnthonyERizzardi1,ArthurTJohnson1,RachelIsakssonVogel2,StefanEPambuccian1,JonathanHenriksen1,3,
AmyPNSkubitz1,3,GregoryJMetzger4andStephenCSchmechel1,3*
Abstract:Immunohistochemical(IHC)assaysperformedonformalin-fixedparaffin-embedded(FFPE)tissuesections
traditionallyhavebeensemi-quantifiedbypathologistvisualscoringofstaining.IHCisusefulforvalidating
biomarkersdiscoveredthroughgenomicsmethodsaslargeclinicalrepositoriesofFFPEspecimenssupportthe
constructionoftissuemicroarrays(TMAs)forhighthroughputstudies.DuetotheubiquitousavailabilityofIHC
techniquesinclinicallaboratories,validatedIHCbiomarkersmaybetranslatedreadilyintoclinicaluse.However,the
methodofpathologistsemi-quantificationiscostly,inherentlysubjective,andproducesordinalratherthan
continuousvariabledata.Computer-aidedanalysisofdigitizedwholeslideimagesmayovercometheselimitations.
UsingTMAsrepresenting215ovarianserouscarcinomaspecimensstainedforS100A1,weassessedthedegreeto
whichdataobtainedusingcomputer-aidedmethodscorrelatedwithdataobtainedbypathologistvisualscoring.To
evaluatecomputer-aidedimageclassification,IHCstainingwithinpathologistannotatedandsoftware-classified
areasofcarcinomawerecomparedforeachcase.TwometricsforIHCstainingwereused:thepercentageof
carcinomawithS100A1staining(%Pos),andtheproductofthestainingintensity(opticaldensity[OD]ofstaining)
multipliedbythepercentageofcarcinomawithS100A1staining(OD*%Pos).AcomparisonoftheIHCstainingdata
obtainedfrommanualannotationsandsoftware-derivedannotationsshowedstrongagreement,indicatingthat
softwareefficientlyclassifiescarcinomatousareaswithinIHCslideimages.ComparisonsofIHCintensitydataderived
usingpixelanalysissoftwareversuspathologistvisualscoringdemonstratedhighSpearmancorrelationsof0.88for
%Pos(p0.0001)and0.90forOD*%Pos(p0.0001).Thisstudydemonstratedthatcomputer-ai
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