Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis 英文参考文献.docVIP

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Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis 英文参考文献.doc

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Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis 英文参考文献

Available online /content/8/2/R40 Research article Open Access Vol 8 No 2 Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis Olivier Meyer1, Pascale Nicaise-Roland2, Marie dos Santos2, Colette Labarre2, Maxime Dougados3, Philippe Goupille4, Alain Cantagrel5, Jean Sibilia6 and Bernard Combe7 1Rheumatology Unit, Assistance Publique H?pitaux de Paris, Bichat University Hospital, 75018 Paris, France 2Biological Immunology Department, Assistance Publique H?pitaux de Paris, Bichat University Hospital, 75018 Paris, France 3Rheumatology Unit B, Assistance Publique H?pitaux de Paris, Cochin University Hospital, 75014 Paris, France 4Rheumatology Unit, Trousseau University Hospital, 37044 Tours Cedex 1, France 5Rheumatology Unit, Rangueil University Hospital, 31043 Toulouse Cedex 4, France 6Rheumatology Unit, Hautepierre University Hospital, 67098 Strasbourg Cedex, France 7Rheumatology Unit, Lapeyronie University Hospital, 34296 Montpellier Cedex 5, France Corresponding author: Olivier Meyer, olivier.meyer@bch.aphp.fr Received: 16 Sep 2005 Revisions requested: 10 Oct 2005 Revisions received: 12 Dec 2005 Accepted: 4 Jan 2006 Published: 26 Jan 2006 Arthritis Research Therapy 2006, 8:R40 (doi:10.1186/ar1896) This article is online at: /content/8/2/R40 ? 2006 Meyer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The objective of this study was to evaluate the potential of serially determined anti-cyclic citrullinated peptide (CCP) antibodies for predicting structural joint damage in patients with early rheumatoid arthritis (RA), compared to a single baseline determination. Ninety-nin