Sepsis as a major determinant of outcome in critically ill HIVAIDS patients dont forget acute kidney injury 英文参考文献.docVIP

Lopes and Jorge Critical Care 2012,16:468 /content/16/6/468 LET TER Sepsis as a major determinant of outcome in critically ill HIV/AIDS patients: don’t forget acute kidney injury José António Lopes* and So? a Jorge See related research by Japiassú et al., /content/14/4/R152 In a previous issue of Critical Care, we read with interest the impact of renal dysfunction on patient outcome. the article by Japiassú and colleagues [1] in which severe Here, we would like to underline the prognostic impor- sepsis was analyzed as a major determinant of outcome tance of acute kidney injury (AKI) on the outcome of of critically ill patients with HIV/AIDS. For this purpose, critically ill patients with HIV. AKI is a common compli- the authors prospectively studied 88 HIV-infected cation in this setting and is independently associated with increased mortality. In addition, sepsis is a leading the impact of severe sepsis on 28-day and 6-month cause of AKI among those patients ese ? ndings have also been demonstrated in non-critically ill, hos- pital ized patients with HI patients admitted to the intensive care unit and analyzed mortality e occurrence of severe sepsis was associated with a threefold increased risk of death at these follow-up erefore, the burden of times. Furthermore, cardiovascular and respiratory dys- mortality associated with sepsis could be explained, in func tions were associated with increased mortality. part, by the high incidence of associated AKI. Prompt ose are important ? ndings and improve medical know- recognition and aggressive treatment of sepsis could be ledge on the key factors determining survival in a speci? c crucial in diminishing both the occurrence of AKI and population that has markedly increased in recent years [2]. Surprisingly, however, the authors have not eval