Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice 英文参考文献.docVIP

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Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice 英文参考文献.doc

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Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice 英文参考文献

Comparative Hepatology BioMedCentral Research Open Access Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice Andrea De Gottardi*1,2, Erwin Biecker1, Abraham Koshy1, Dieter Bohler1, Sidney Shaw1, Hans S?gesser1 and Jürg Reichen1 Address: 1Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland and 2Division of Gastroenterology and Hepatology, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland Email: Andrea De Gottardi* - andrea.de-gottardi@alumni.uni-heidelberg.de; Erwin Biecker - erwin.biecker@ukb.uni-bonn.de; Abraham Koshy - koshyabe@; Dieter Bohler - perlentaucher34@gmx.ch; Sidney Shaw - sidney.shaw@dkf.unibe.ch; Hans S?gesser - hans.saegesser@ikp.unibe.ch; Jürg Reichen - reichen@ikp.unibe.ch * Corresponding author Published: 05 December 2006 Received: 06 April 2006 Accepted: 05 December 2006 Comparative Hepatology 2006, 5:9 doi:10.1186/1476-5926-5-9 This article is available from: /content/5/1/9 ? 2006 De Gottardi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Therefore, we hypothesized sensitivity to endothelin to be increased in mice lacking the endothelial cell NO synthase gene. Response of vascular resistance to endothelin was assessed in the in situ perfused liver of endothelial constitutive nitric oxide synthase (ecNOS) knockout and wild type mice. Livers were also harvested for RNA and protein is