Semen quality in Peruvian pesticide applicators association between urinary organophosphate metabolites and semen parameters 英文参考文献.docVIP

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Semen quality in Peruvian pesticide applicators association between urinary organophosphate metabolites and semen parameters 英文参考文献.doc

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Semen quality in Peruvian pesticide applicators association between urinary organophosphate metabolites and semen parameters 英文参考文献

Environmental Health BioMedCentral Research Open Access Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters Sandra Yucra*1,2, Manuel Gasco1,2, Julio Rubio1,2 and Gustavo F Gonzales1,2 Address: 1Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru and 2Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P.O. Box 1843, Lima, Peru Email: Sandra Yucra* - 23411@.pe; Manuel Gasco - 05931@.pe; Julio Rubio - 09008@.pe; Gustavo F Gonzales - ggr@.pe * Corresponding author Published: 17 November 2008 Received: 31 January 2008 Accepted: 17 November 2008 Environmental Health 2008, 7:59 doi:10.1186/1476-069X-7-59 This article is available from: /content/7/1/59 ? 2008 Yucra et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Organophosphates are broad class of chemicals widely used as pesticides throughout the world. We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru. Methods: Thirty-one men exposed to organophosphate (OP) pesticides and 31 non-exposed were recruited (age, 20–60 years). In exposed subjects, semen and a blood sample were obtained one day after the last pesticide application. Subjects were grouped according to levels of OP metabolites in urine. Semen samples were analyzed for sperm concentration, percentage of sperm motility, percentage of normal morphology, semen leucocytes and concentrations of fructose and zinc. Exposure t