Seleno-enzymes and seleno-compounds the two faces of selenium 英文参考文献.docVIP

Available online /content/10/6/180 Commentary Seleno-enzymes and seleno-compounds: the two faces of selenium Xavier Forceville Ch Meaux, Réanimation Polyvalente, 6–8 rue Saint Fiacre, 77104 Meaux, France Corresponding author: Xavier Forceville, xforceville@ Published: 13 December 2006 Critical Care 2006, 10:180 (doi:10.1186/cc5109) This article is online at /content/10/6/180 ? 2006 BioMed Central Ltd See related research by Berger et al., /content/10/5/R153 Abstract water (NF-κB, acid arachidonic and complement cascades, and mitochondria) [6,8]. As a consequence, selenium has been found to improve immunity [6,7]. In septic shock patients there is a dramatic and early decrease of the plasma selenium concentration [9]. Selenium protects cells and inhibits many inflammatory cell mechanisms through antioxidant seleno-enzymes. Immunity improve- ment is illustrated by the study of Berger and colleagues, with reduction of nosocomial pneumonia in burnt patients under multi- trace-element supplementation. As seleno-compounds (especially sodium selenite) are pro-oxidant, however, administration above 800μg/day may be dangerous in septic shock. Paradoxically, direct reversible pro-oxidative effects of seleno-compounds may also be beneficial for reduction of inflammation (genomic action, apoptosis), and may even be bactericidal or virucidal. These facts need to be further examined, as well as the possible dramatic drop of plasma selenoprotein P in septic shock and its role in endo- thelium protection. In the previous issue of Critical Care, Berger and colleagues [1] reported the results of a very interesting aggregative study on a group of 41 severely burnt patients. The authors show a significant reduction of nosocomial pneumonia by intravenous multitrace-element supplements (copper, selenium, and zinc). These results confirm Berger’s research on burnt and trauma patients conduc