Selenoprotein P Controls Oxidative Stress in Cornea 英文参考文献.docVIP

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Selenoprotein P Controls Oxidative Stress in Cornea 英文参考文献.doc

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Selenoprotein P Controls Oxidative Stress in Cornea 英文参考文献

SelenoproteinPControlsOxidativeStressinCornea AkihiroHiguchi1*,KazuhikoTakahashi2,MasakiHirashima3,TetsuyaKawakita4,KazuoTsubota1,4 1CenterforIntegratedMedicalResearch, SchoolofMedicine,KeioUniversity,Tokyo,Japan, 2Department ofNutritionalBiochemistry,SchoolofPharmacy, Hokkaido Pharmaceutical University, Hokkaido, Japan, 3Research Department 1, The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan, 4Department of Ophthalmology,SchoolofMedicine,KeioUniversity,Tokyo,Japan Abstract Theocularsurfaceisalwaysattackedbyoxidativestress,andcorneaepithelialcellsaresupposedtohavetheirownrecovery systemagainstoxidativestress.Thereforewehypothesizedthattearssupplykeymoleculesforpreventingoxidativestress incornea.ThepotentialtargetkeymoleculewefocusedisselenoproteinP(SeP).SePisacarrierofselenium,whichisan essentialtraceelementformanyanimals,foroxidativestressmetabolismintheorganism,andwasextremelyexpressedin lacrimalgland.AnexperimentwasperformedwithSePeyedropsinaratdryeyemodel,preparedbyremovingthelacrimal glands. The anticipated improvement in corneal dry eye index and the suppression of oxidative stress markers were observed in SeP eye drop group. Furthermore, the concentration of SeP was significantly higher in dry eye patients comparedwithnormalvolunteers.Collectively,weconcludedthattearSePisakeymoleculetoprotecttheocularsurface cellsagainstenvironmentaloxidativestress. Citation: Higuchi A, Takahashi K, Hirashima M, Kawakita T, Tsubota K (2010) Selenoprotein P Controls Oxidative Stress in Cornea. PLoS ONE 5(3): e9911. doi:10.1371/journal.pone.0009911 Editor:ShuktiChakravarti,JohnsHopkinsUniversity,UnitedStatesofAmerica ReceivedSeptember8,2009;AcceptedFebruary3,2010;PublishedMarch29,2010 Copyright: ? 2010 Higuchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thestudyre