Self-Assembly in Monoelaidin Aqueous Dispersions Direct Vesicles to Cubosomes Transition 英文参考文献.docVIP

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Self-Assembly in Monoelaidin Aqueous Dispersions Direct Vesicles to Cubosomes Transition 英文参考文献.doc

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Self-Assembly in Monoelaidin Aqueous Dispersions Direct Vesicles to Cubosomes Transition 英文参考文献

Self-AssemblyinMonoelaidinAqueousDispersions: DirectVesiclestoCubosomesTransition AnanYaghmur1*,PeterLaggner1,MatsAlmgren2,MichaelRappolt1 1InstituteofBiophysicsandNanosystemsResearch(IBN),AustrianAcademyofSciences,Graz,Austria,2DepartmentofPhysicalChemistry,UppsalaUniversity,Uppsala, Sweden Abstract Background:Inthepresentstudy,synchrotronsmall-angleX-rayscattering(SAXS)andCryo-TEMwereusedtocharacterize thetemperature-inducedstructuraltransitionsofmonoelaidin(ME)aqueousdispersioninthepresenceofthepolymeric stabilizerF127.Weprovethatthedirecttransitionfromvesiclestocubosomesbyheatingthisdispersionispossible.The obtainedresultswerecomparedwiththefullyhydratedbulkMEphase. Methodology/PrincipalFindings:OurresultsindicatetheformationofMEdispersion,whichislessstablethanthatbased on the congener monoolein (MO). In addition, the temperature-dependence behavior significantly differs from the fully hydrated bulk phase. SAXS findings indicate a direct La-V2 internal transition in the dispersion. While the transition temperature is conserved in the dispersion, the formed cubosomes with internal Im3m symmetry clearly contain more waterandthisorderedinteriorisretainedoverawidertemperaturerangeascomparedtoitsfullyhydratedbulksystem.At 25uC,Cryo-TEMobservationsrevealtheformationofmostlikelycloselypackedonion-likevesicles.Abovethelamellarto non-lamellar phase transition at 65uC, flattened cubosomes with an internal nanostructure are observed. However, they haveonlyarbitraryshapesandthus,theirmorphologyissignificantlydifferentfromthatofthewell-shapedanalogousMO cubosomeandhexosomeparticles. Conclusions/Significance:Ourstudyrevealsadirectliposomes-cubosomestransitioninMEdispersion.Theobtainedresults suggest that the polymeric stabilizer F127 especially plays a significant role in the membrane fusion processes. F127 incorporatesinconsiderableamountintotheinternalnanostructureandleadstotheformationofahighlyswollenIm3m phase. Citation:YaghmurA,LaggnerP,AlmgrenM,RappoltM(2008)Self-Asse