Selective Genomic Copy Number Imbalances and Probability of Recurrence in Early-Stage Breast Cancer 英文参考文献.docVIP

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Selective Genomic Copy Number Imbalances and Probability of Recurrence in Early-Stage Breast Cancer 英文参考文献.doc

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Selective Genomic Copy Number Imbalances and Probability of Recurrence in Early-Stage Breast Cancer 英文参考文献

SelectiveGenomicCopyNumberImbalancesand ProbabilityofRecurrenceinEarly-StageBreastCancer PatriciaA.Thompson1*,AbenaaM.Brewster2, Kim-AnhDo3,VeerabhadranBaladandayuthapani3, BradleyM.Broom4,MaryE.Edgerton5,KarinM.Hahn6,JamesL.Murray6,AysegulSahin4 ,Spyros Tsavachidis7,YukerWang8,LiZhang3,GabrielN.Hortobagyi6,GordonB.Mills9,MelissaL.Bondy7 1DepartmentofCellularandMolecularMedicine,ArizonaCancerCenter,UniversityofArizona,Tucson,Arizona,UnitedStatesofAmerica,2DepartmentofClinicalCancer Prevention, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States of America, 3Department of Biostatistics, MD Anderson Cancer Center, UniversityofTexas,Houston,Texas, UnitedStatesofAmerica, 4DepartmentofBioinformaticsandComputational Biology,MDAndersonCancerCenter,Universityof Texas,Houston,Texas,UnitedStatesofAmerica,5DepartmentofPathology,MDAndersonCancerCenter,UniversityofTexas,Houston,Texas,UnitedStatesofAmerica, 6DepartmentofBreastMedicalOncology,MDAndersonCancerCenter,UniversityofTexas,Houston,Texas,UnitedStatesofAmerica,7DepartmentofEpidemiology,MD AndersonCancerCenter,UniversityofTexas,Houston,Texas,UnitedStatesofAmerica,8AffymetrixInc.,SantaClara,California,UnitedStatesofAmerica,9Departmentof SystemsBiology,MDAndersonCancerCenter,UniversityofTexas,Houston,Texas,UnitedStatesofAmerica Abstract Anumberofstudiesofcopynumberimbalances(CNIs)inbreasttumorssupportassociationsbetweenindividualCNIsand patientoutcomes.However,nopatternorsignatureofCNIshasemergedforclinicaluse.Wedeterminedcopynumber(CN) gainsandlossesusinghigh-densitymolecularinversionprobe(MIP)arraysfor971stageI/IIbreasttumorsandapplieda boostingstrategytofithazardsmodelsforCNandrecurrence,treatingchromosomalsegmentsinadose-specificfashion(-1 [loss],0[nochange]and+1[gain]).Theconcordanceindex(C-Index)wasusedtocompareprognosticaccuracybetweena training(n=728)andtest(n=243)setandacrossmodels.TwelvenovelprognosticCNIswereidentified:lossesat1p12, 12q13.13,13q12.3,22q11,andXp21,andgainsat2p11.1