Selective Expression of KCNS3 Potassium Channel α-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex 英文参考文献.docVIP

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Selective Expression of KCNS3 Potassium Channel α-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex 英文参考文献.doc

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Selective Expression of KCNS3 Potassium Channel α-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex 英文参考文献

SelectiveExpressionofKCNS3PotassiumChannel a-SubunitinParvalbumin-ContainingGABANeuronsin theHumanPrefrontalCortex DankoGeorgiev1,GuillermoGonza′lez-Burgos2,MitsuruKikuchi1,3,YoshioMinabe1,3,DavidA.Lewis2,4 , TakanoriHashimoto1,2 * 1Department of Psychiatry and Neurobiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan, 2Department of Psychiatry, UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica,3ResearchCenterforChildMentalDevelopment,KanazawaUniversity,Kanazawa,Ishikawa, Japan,4DepartmentofNeuroscience,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica Abstract ThecognitivedeficitsofschizophreniaappeartobeassociatedwithalteredcorticalGABAneurotransmissioninthesubsets ofinhibitoryneuronsthatexpresseitherparvalbumin(PV)orsomatostatin(SST).Identificationofmolecularmechanisms thatoperateselectivelyintheseneuronsisessentialfordevelopingtargetedtherapeuticstrategiesthatdonotinfluence othercelltypes.Consequently,wesoughttoidentify,inthehumancortex,geneproductsthatareexpressedselectivelyby PVand/orSSTneurons,andthatmightcontributetotheirdistinctivefunctionalproperties.Basedonpreviouslyreported expression patterns in the cortex of mice and humans, we selected four genes: KCNS3, LHX6, KCNAB1, and PPP1R2, + + encoding K channel Kv9.3 modulatory a-subunit, LIM homeobox protein 6, K channel Kvb1 subunit, and protein phosphatase1regulatorysubunit2,respectively,andexaminedtheircolocalizationwithPVorSSTmRNAsinthehuman prefrontalcortexusingdual-labelinsituhybridizationwith35S-anddigoxigenin-labeledantisenseriboprobes.KCNS3mRNA was detected in almost all PV neurons, but not in SST neurons, and PV mRNA was detected in .90% of KCNS3 mRNA- expressingneurons.LHX6mRNAwasdetectedinalmostallPVand.90%ofSSTneurons,whileamongallLHX6mRNA- expressingneurons50%expressedPVmRNAand.44%expressedSSTmRNA.KCNAB1andPPP1R2mRNAsweredetected inmuchlargerpopulationsofcorticalneuronsthanPVorSSTneurons.ThesefindingsindicatethatKCNS3i