Serum sickness-like reaction associated with cefazolin 英文参考文献.docVIP

BMC Clinical Pharmacology BioMedCentral Case report Open Access Serum sickness-like reaction associated with cefazolin Michael Brucculeri*?1, Marian Charlton?2 and David Serur?2 Address: 1Division of Nephrology and Hypertension, New York Presbyterian Hospital – Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA and 2The Rogosin Institute, New York Presbyterian Hospital – Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA Email: Michael Brucculeri* - mjb69@; Marian Charlton - mbc2001@; David Serur - serurd@ * Corresponding author ?Equal contributors Published: 23 February 2006 Received: 20 October 2005 Accepted: 23 February 2006 BMC Clinical Pharmacology 2006, 6:3 doi:10.1186/1472-6904-6-3 This article is available from: /1472-6904/6/3 ? 2006 Brucculeri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Although rare, serum sickness-like reactions have been documented to occur following the administration of many antibiotics. Cefazolin, a first generation cephalosporin, is a commonly prescribed antibiotic which is considered to be generally safe and well tolerated. There have been no prior reports linking this drug with sickness-like reactions. We report a probable case of serum sickness-like reaction following a single dose of cefazolin. Case Presentation: A 23 year old man with no significant past medical history was admitted to undergo a laparoscopic donor nephrectomy as part of a living-related renal transplant. One gram of intravenous cefazolin was administered perioperatively. The surgery was completed without complication and the remainder of his hospital course was uneventful. Ten days f