Serum level of semicarbazide-sensitive amine oxidase in children with ADHD 英文参考文献.docVIP

Behavioral and Brain Functions BioMedCentral Short paper Open Access Serum level of semicarbazide-sensitive amine oxidase in children with ADHD Veit Roessner*1, Henrik Uebel1, Andreas Becker1, Georg Beck2, Stefan Bleich2 and Aribert Rothenberger1 Address: 1Department of Child and Adolescent Psychiatry, University of Goettingen, Von-Siebold-Str. 5, D-37075 Goettingen, Germany and 2Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany Email: Veit Roessner* - vroessn@gwdg.de; Henrik Uebel - huebel@gwdg.de; Andreas Becker - abecker4@gwdg.de; Georg Beck - georg.beck@klab.imed.uni-erlangen.de; Stefan Bleich - stefan.bleich@psych.imed.uni-erlangen.de; Aribert Rothenberger - arothen@gwdg.de * Corresponding author Published: 27 January 2006 Received: 26 October 2005 Accepted: 27 January 2006 Behavioral and Brain Functions 2006, 2:5 doi:10.1186/1744-9081-2-5 This article is available from: /content/2/1/5 ? 2006 Veit et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The objective of this study was to analyze the extracellularly acting semicarbazide- sensitive amine oxidase (SSAO) serum levels in children with ADHD for the first time. SSAO is known to show deviations from normal in various somatic disorders and to interplay with the intracellularly active MAO. In humans two forms of SSAO a circulating form in plasma and a membrane-bound form are involved in monoaminergic metabolism. Methods: We analyzed serum levels of SSAO in 27 children meeting ICD-10 criteria of Hyperkinetic Disorder (F90) or DSM-IV criteria of ADHD combined type by HPLC method and fluorimetric detection. A group of 42 healthy vol