Serum 25-Hydroxyvitamin D and Risk of Lung Cancer in Male Smokers A Nested Case-Control Study 英文参考文献.docVIP

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Serum 25-Hydroxyvitamin D and Risk of Lung Cancer in Male Smokers A Nested Case-Control Study 英文参考文献.doc

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Serum 25-Hydroxyvitamin D and Risk of Lung Cancer in Male Smokers A Nested Case-Control Study 英文参考文献

Serum25-HydroxyvitaminDandRiskofLungCancerin MaleSmokers:ANestedCase-ControlStudy StephanieJ.Weinstein1*,KaiYu1,RonaldL.Horst2,DominickParisi3,JarmoVirtamo4 ,Demetrius Albanes1 1DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica,2HeartlandAssays, Inc.,Ames,Iowa,UnitedStatesofAmerica,3InformationManagementServices,Inc.,SilverSpring,Maryland,UnitedStatesofAmerica,4DepartmentofChronicDisease Prevention,NationalInstituteforHealthandWelfare,Helsinki,Finland Abstract Background:AroleforvitaminDincancerriskreductionhasbeenhypothesized,butfewdataexistforlungcancer.We investigatedtherelationshipbetweenvitaminDstatus,usingcirculating25-hydroxyvitaminD[25(OH)D],andlungcancer risk in anestedcase-control study within theAlpha-Tocopherol, Beta-CaroteneCancer Prevention Studyof Finnishmale smokers. Methods:Lungcancercases(n=500)wererandomlyselectedbasedonmonthofbloodcollection,and500controlswere matched to them based on age and blood collection date. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate-adjusted conditional logistic regression. To account for seasonal variation in 25(OH)D concentrations, season-specific and season-standardized quintiles of 25(OH)D were examined, and models were also stratified on season of blood collection (darker season=November–April and sunnier season=May–October). Pre- determined,clinically-definedcutpointsfor25(OH)Dand25(OH)Dasacontinuousmeasurewerealsoexamined. Results:Overall,25(OH)Dwasnotassociatedwithlungcancer.Riskswere1.08(95%CI0.67–1.75)and0.83(95%CI0.53– 1.31)inthehighestvs.lowestseason-specificandseason-standardizedquintilesof25(OH)D,respectively,and0.91(95%CI 0.48–1.72)forthe$75vs.,25nmol/Lclinicalcategories.Inverseassociationswere,however,suggestedforsubjectswith bloodcollectionsfromNovember–April,withORsof0.77(95%CI0.41–1.45,p-trend=0.05)and0.65(95%CI0.37–1.14,p- trend=0.07)inthehighestvs.lowestseason-specificandsea