Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition 英文参考文献.docVIP

Molecules 1998, 3, 80–87 molecules ISSN 1420-3049 Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition* Tuvia Sheradsky** and Elliad R. Silcoff Department of Organic Chemistry, the Hebrew University, Jerusalem 91904, Israel. Tel.+972 2 658 5284, Fax +972 2 658 5345, Email stuvia@vms.huji.ac.il Received: 15 January 1998 / Accepted: 23 February 1998 / Published: 24 February 1998 Abstract: The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso d