Synthetic lethality a framework for the development of wiser cancer therapeutics 英文参考文献.docVIP

Review Synthetic lethality: a framework for the development of wiser cancer therapeutics William G Kaelin Jr Address: Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, 44 Binney St, Boston, MA 02115, USA. Email: william_kaelin@ from high-throughput screens for cytotoxic agents were historically prioritized using factors such as potency, ease Abstract The challenge in medical oncology has always been to identify compounds that will kill, or at least tame, cancer cells while leaving normal cells unscathed. Most chemotherap