Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities 英文参考文献.docVIP

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Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities 英文参考文献.doc

Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities 英文参考文献

Bainbridgeetal.GenomeBiology2011,12:R68 /2011/12/7/R68 RESEARCH OpenAccess Targetedenrichmentbeyondtheconsensus codingDNAsequenceexomerevealsexonswith highervariantdensities MatthewNBainbridge1,2,MinWang1,YuanqingWu1,IreneNewsham1,DonnaMMuzny1,JohnLJefferies3, ThomasJAlbert4,DanielLBurgess4andRichardAGibbs1* Abstract Background:EnrichmentoflocibyDNAhybridization-capture,followedbyhigh-throughputsequencing,isan importanttoolinmoderngenetics.Currently,themostcommontargetsforenrichmentaretheproteincoding exonsrepresentedbytheconsensuscodingDNAsequence(CCDS).TheCCDS,however,excludesmanyactualor

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Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities 英文参考文献.docVIP