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Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment 英文参考文献.docVIP

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Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment 英文参考文献.doc

    Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment 英文参考文献

    Girgisetal.EJNMMIResearch2011,1:24 /content/1/1/24 ORIGINAL RESEARCH OpenAccess TargetingCEAinPancreasCancerXenografts withaMutatedscFv-FcAntibodyFragment MarkDGirgis1,3,ToveOlafsen2,VaniaKenanova2,KatelynEMcCabe2,AnnaMWu2andJamesSTomlinson1,3* Abstract Background:Sensitiveantibody-basedtumortargetinghasthepotentialnotonlytoimagemetastaticand micrometastaticdisease,butalsotobethebasisoftargetedtherapy.Thevastmajorityofpancreascancersexpress carcinoembryonicantigen(CEA).Thus,wesoughttoevaluatethepotentialofCEAasapancreaticcancertarget utilizingarapidlyclearingengineeredanti-CEAscFv-Fcantibod

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