The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens 英文参考文献.docVIP
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The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens 英文参考文献
Fuetal.BehavioralandBrainFunctions2012,8:20
/content/8/1/20
RESEARCH
OpenAccess
Thegamma-aminobutyricacidtypeB(GABAB)
receptoragonistbaclofeninhibitsmorphine
sensitizationbydecreasingthedopaminelevelin
ratnucleusaccumbens
ZhenyuFu1,2?,HongfaYang1?,YuqiangXiao2,GangZhao1andHaiyanHuang1*
Abstract
Background:Repeatedmorphineexposurecaninducebehavioralsensitization.Thereareevidenceshaveshown
thatcentralgamma-aminobutyricacid(GABA)systemisinvolvedinmorphinedependence.However,theeffectofa
GABABreceptoragonistbaclofenonmorphine-inducedbehavioralsensitizationinratsisunclear.
Methods:Weusedmorphine-i
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