The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years 英文参考文献.docVIP
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The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years 英文参考文献
Soto-Ramírezetal.ClinicalEpigenetics2013,5:1
/content/5/1/1
RESEARCH
OpenAccess
TheinteractionofgeneticvariantsandDNA
methylationoftheinterleukin-4receptorgene
increasetheriskofasthmaatage18years
NelísSoto-Ramírez1,SyedHasanArshad2,6,JohnWHolloway2,3,HongmeiZhang1,EricSchauberger4,SusanEwart5,
VeereshPatil2,6andWilfriedKarmaus1*
Abstract
Background:Theoccurrenceofasthmaisweaklyexplainedbyknowngeneticvariants.Epigeneticmarks,DNA
methylation(DNA-M)inparticular,areconsideredtoaddtotheexplanationofasthma.However,noetiological
modelhasyetbeendevelopedthatintegratesgeneticvariantsandDNA-M.Toexplor
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