The next frontier of systems biology higher-order and interspecies interactions 英文参考文献.docVIP

Fischbach and Krogan Genome Biology 2010,11:208 /2010/11/5/208 RE VIE W The next frontier of systems biology: higher-order and interspecies interactions Michael A Fischbach * and Nevan J Krogan * 1 2 complexes in the budding yeast Saccharomyces cerevisiae, many of which were previously unknown [3,4] (Figure 1a). Global e?orts to de?ne protein complexes have been extended to the prokaryotes Escherichia coli [5,6] and Mycoplasma pneumoniae [7] as well as to mammalian cells [8,9]. Highlighting the power of