Rac-ing upstream to treat rheumatoid arthritis.docVIP

Firestein Arthritis Research Therapy 2010,12:109 /content/12/1/109 EDITORIAL ‘Rac’-ing upstream to treat rheumatoid arthritis Gary S Firestein* See related research by Abreu et al., /content/12/1/R2 question now is not whether some of these agents can be Abstract e? ective; rather, it is whether the toxicity and side e? ects Signal transduction pathways regulate the production and function of many cytokines implicated in immune- mediated diseases. Targeting these enzymes with small molecule inhibitors represents a fertile ?eld for the treatment of rheumatoid arthritis. Recent successes wi