A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis.docVIP

Abreu et al: Arthritis Research Therapy 2010, 12:R2 /content/12/1/R2 RESEARCH ARTICLE Open Access A Rac1 inhibitory peptide suppresses antibody Research article production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis Joana RF Abreu1, Wendy Dontje1, Sarah Krausz1, Daphne de Launay1, Paula B van Hennik2, Anne-Marieke van Stalborch2, Jean-Paul ten Klooster2, Marjolein E Sanders1, Kris A Reedquist1, Margriet J Vervoordeldonk1,3, Peter L Hordijk2 and Paul P Tak*1 Abstract Introduction: The Rho family GTPase Rac1 regulates cytoskeletal rearrangem