A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements.docVIP

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A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements.doc

A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements

Enrothetal.AlgorithmsforMolecularBiology2012,7:2 /content/7/1/2 RESEARCH OpenAccess Astrandspecifichighresolutionnormalization methodforchip-sequencingdataemploying multipleexperimentalcontrolmeasurements StefanEnroth1,5?,ClaesRAndersson2?,RobinAndersson1,6,ClaesWadelius3,MatsGGustafsson1,2 and JanKomorowski1,4* Abstract Background:High-throughputsequencingisbecomingthestandardtoolforinvestigatingprotein-DNAinteractions orepigeneticmodifications.However,thedatageneratedwillalwayscontainnoiseduetoe.g.repetitiveregionsor non-specificantibodyinteractions.Thenoisewillappearintheformofaback

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A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements.docVIP