Aberrant CD200CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.docVIP

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Aberrant CD200CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.doc

Aberrant CD200CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity

Lietal.ArthritisResearchTherapy2012,14:R123 /content/14/3/R123 RESEARCH ARTICLE OpenAccess AberrantCD200/CD200R1expressionand functioninsystemiclupuserythematosus contributestoabnormalT-cellresponsiveness anddendriticcellactivity YangLi1?,Li-danZhao1?,Lu-shaTong1?,Su-ningQian1,YanRen1,LeiZhang1,XinDing1,YangChen1, Yan-xiaWang1,WenZhang1,Xiao-fengZeng1,Feng-chunZhang1,Fu-linTang1,XuanZhang1*,De-nianBa2, WeiHe2,Xue-taoCao2andPeterELipsky3* Abstract Introduction:CD200isatypeItransmembraneglycoproteinthatcanregulatetheactivationthresholdof inflammatoryimmuneresponses,polarizecytokineproduction,

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Aberrant CD200CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.docVIP