A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients.docVIP

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A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients.doc

A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients

Spruijtetal.CriticalCare2010,14:R150 /content/14/4/R150 RESEARCH OpenAccess Asystematicreviewofrandomizedcontrolled trialsexploringtheeffectofimmunomodulative interventionsoninfection,organfailure,and mortalityintraumapatients NicoleESpruijt,TjaakjeVisser,LukePHLeenen* Abstract Introduction:Followingtrauma,patientsmaysufferanoverwhelmingpro-inflammatoryresponseandimmune paralysisresultingininfectionandmultipleorganfailure(MOF).Variouspotentiallyimmunomodulative interventionshavebeentested.Theobjectiveofthisstudyistosystematicallyreviewtherandomizedcontrolled trials(RCTs)thatinvestigatetheeff

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