A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients.docVIP
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A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients
Spruijtetal.CriticalCare2010,14:R150
/content/14/4/R150
RESEARCH
OpenAccess
Asystematicreviewofrandomizedcontrolled
trialsexploringtheeffectofimmunomodulative
interventionsoninfection,organfailure,and
mortalityintraumapatients
NicoleESpruijt,TjaakjeVisser,LukePHLeenen*
Abstract
Introduction:Followingtrauma,patientsmaysufferanoverwhelmingpro-inflammatoryresponseandimmune
paralysisresultingininfectionandmultipleorganfailure(MOF).Variouspotentiallyimmunomodulative
interventionshavebeentested.Theobjectiveofthisstudyistosystematicallyreviewtherandomizedcontrolled
trials(RCTs)thatinvestigatetheeff
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