Abnormalities of T cell signaling in systemic lupus erythematosus.docVIP

Moulton and Tsokos Arthritis Research Therapy 2011, 13:207 /content/13/2/207 RE VIE W Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton* and George C Tsokos bear characteristics reminiscent of activated/memory Abstract T cells, such as the overall increased tyrosine phosphory- Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and in?ammatory cell in?ltration in target lation of signaling intermediates, accelerated calcium ? ux res