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- 2017-05-15 发布于上海
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A systematic screen reveals new elements acting at the G2M cell cycle control
NavarroandNurseGenomeBiology2012,13:R36
/2012/13/5/R36
RESEARCH
OpenAccess
Asystematicscreenrevealsnewelementsacting
attheG2/Mcellcyclecontrol
FranciscoJNavarro1*andPaulNurse1,2,3
Abstract
Background:ThemajorcellcyclecontrolactingattheG2tomitosistransitionistriggeredinalleukaryotesby
cyclin-dependentkinases(CDKs).InthefissionyeastSchizosaccharomycespombetheactivationoftheG2/MCDKis
regulatedprimarilybydephosphorylationoftheconservedresidueTyr15inresponsetothestress-nutritional
responseandcellgeometrysensingpathways.ToobtainamorecompleteviewoftheG2/Mcontrolwehave
screenedsystematicallyforgened
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