血清胸腺激酶1在转移性结直肠癌患者化疗前后检测的意义.pdfVIP

西部医学 2016 年 9 月第 28 卷第 9 期 Med J West China , September 2016 , Vo l. 28 , No. 9 • 1257 • ·论著· 血清胸腺激酶 1 在转移性结直肠癌患者化疗前后 检测的意义骨 安宁张明兰海涛李宏敏 (四川省医学科学院·四川省人民医院肿瘤科，四川成都 610072) E摘要I 目的 探讨血清胸腺激酶 1CS-TKl)在转移性结直肠癌患者化疗前后检测的意义。方法 采用免疫印迹 增强化学发光法检测 45 例转移性结直肠癌患者(给直肠癌纽)和 33 例健康体检者(正常对照纽)的S-TKl 水平。结果 转移性结直肠癌患者的S-TK1 水平高于健康体检者CPO. 05); 化疗后无疾病进展的转移性结直肠癌患者S-TK1 水平 较化疗前呈下降趋势(PO.O日，疾病进展的患者S-TK1 水平较化疗前上升CPO. 05); 转移性结直肠癌患者化疗前的 S-TKl 水平与其 KPS 评分有一定的相关性(PO.O日。结论 监测S-TK1 水平对评估转移性结直肠癌患者的化疗疗 效具有一定的临床应用价值。 E关键词】 血清胸腺激酶 1 ;转移性结直肠癌;化疗 E 申图分类号】 R 735. 3 【文献标志码】 A doi: 10. 3969/j. issn. 1672-3511. 2016. 09. 019 Significance of detecting serum thymidine kinase 1 in metastatic large intestine carcinoma before and after chemotherapy AN Ning , ZHANG Ming , LAN Haitao ,et al CSichuan Academy 0/ Medical Sciences Sichuan Provincial People s Hospital , Chengdu 610072 , China) Abstract) Objective To explore the significance of detecting serum thymidine kinase 1 CS-TK l) in metastatic large intestine carcinoma before and after chemotherapy. Methods Enhanced chemiluminescence assay was used to detect the S-TKl levels in 45 patients with metastatic large intestine carcinorna and 33 normal controls. Results The S-TKl level in the patients with metastatic large intestine carcinoma was significantly higher than that in the normal controls (PO. 05). Compared with those before chemotherapy ,the S-TKl levels were significantly decreased in the metastatic large intestine carcinorna with disease under control after chemotherapy( P 0.05). S-TK1 levels were significantly in-